Total Synthesis of Bioactive Natural Products - A Personal Perspective
نویسنده
چکیده
Total synthesis of complex molecular architectures has long been recognized as the most powerful form of training for synthetic organic chemists. This historical discipline has a rich and glorious tradition in both teaching and research, and is an indispensible component in any chemistry department and scientific institutions. Scientifically, in addition to the synthetic challenges associated with the unprecedented molecular architectures, total synthesis serves as a platform for uncovering novel chemical reactivities and enables the understanding of chemo-, regioand stereoselectivities in complex molecular systems. As such, this powerful vehicle for the invention of new synthetic strategies and methodologies, particularly concerning atom-atom bond forming/breaking reactions, catalysis, and asymmetric inductions, has a cemented position in synthetic organic chemistry.
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